Cisplatin and kidney damage

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August undefined, 2024

WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms … WebNov 12, 2024 · Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.Nausea and Vomiting: cisplatin injection can cause severe …

Natural products: potential treatments for cisplatin …

Webwww.ncbi.nlm.nih.gov WebCisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, ... As opposed to immune-mediated CIT, the release of ROS occurs downstream in the signalling pathway of cisplatin-induced damage in healthy cells. Because the significance of ROS as the damage-causing agent has been established in CIT, it is only … city lights lounge in chicago

Cisplatin-Induced Acute Kidney Injury and Renal Salt Wasting …

WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has … WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and neck, bladder, ovarian, and testicular malignanc Cisplatin-Induced Acute Kidney Injury and Renal Salt Wasting Syndrome Federal Practitioner WebOct 22, 2024 · As repeated injections of 6 mg/kg cisplatin in a one-week interval did not cause apparent kidney injury and those of 10 mg/kg cisplatin accelerated kidney injury without causing lethality,... city lights judge judy

Cisplatin Side Effects: Common, Severe, Long Term - Drugs.com

The use of cisplatin in patients after kidney... : Medicine

WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and … WebCisplatin and kidney damage Kent Cass Member Posts: 1,898 Member January 2010 edited March 2014 #1 The subject of kidney damage as a result of chemo by Cisplatin … city lights menu cumberland mdWebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and … city lights jazz festival in las vegas

"WebApr 12, 2024 · The main risk factors related to the AKI onset in neoplastic patients are the (i) metabolic alterations associated with cancer (such as tumor lysis syndrome-TLS, uric acid nephropathy and hypercalcemia), (ii) the hematopoietic stem-cell transplantation (HSCT) that is often complicated by AKI, (iii) the use of nephrotoxic chemotherapeutic agents … " - Cisplatin and kidney damage

Cisplatin and kidney damage

Proposed mechanism for cisplatin/CYP450 dependent kidney damage…

WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause... WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or …

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WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has …

WebMar 9, 2024 · Cisplatin is mainly excreted through the kidneys. It becomes concentrated during excretion, and the concentration in renal tubular epithelial cells is much higher …

WebAug 24, 2024 · Damage to non-cancer cells can occur while the body works to metabolize and excrete the drug. “Although the body excretes 50% to 80% of the administered cisplatin within a day or so, some remains in the kidney, where it damages specific cells in the nephron, which removes waste from the blood before it is converted to urine,” Dr. Zhao … WebKidney damage To help prevent kidney damage, it is important to drink plenty of water. You might also have fluids into your vein before, during and after treatment. You have blood tests before your treatments to check how well your …

WebAug 6, 2014 · The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney.

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … city lights maintenanceWebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [ 29, 30 ]. In addition, nicotinamide prevents apoptosis in different cellular injury paradigms [ 31 ]. city lights milwaukeeWebMay 8, 2024 · Nephrotoxicity With Cisplatin Patients may accumulate metabolites in the renal proximal tubule cells of the kidneys, where 90% of cisplatin undergoes urinary excretion, Duffy et al. explained. This causes a trifecta of factors: direct inflammation, production of reactive oxygen species leading to oxidative cell damage, and cell death. city lights kkl