WebNumerous DNA- and RNA-level functions are embedded in protein-coding regions, which constrains their structure, function, and evolution. Accumulating evidence suggests that such additional, overlapping functions occur preferentially in the coding sequences of intrinsically disordered proteins/regions (IDPs/IDRs), especially in those that are newly incorporated … WebA 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose coding region is covered with ribosomes.
mTORC2 deploys the mRNA binding protein IGF2BP1 to regulate …
WebDownload scientific diagram All hnRNP D isoforms effectively block mRNA decay directed by the c- fos coding region instability determinants. (A) RNA blots showing decay of a hybrid mRNA ... WebNov 1, 1998 · A cytoplasmic protein, the coding region determinant-binding protein (CRD-BP), binds in vitro to the c- myc coding region instability determinant. We have proposed that the CRD-BP, when bound to the mRNA, shields the mRNA from endonucleolytic attack and thereby prolongs the mRNA half-life. Here we report the cloning and further … goodmorn tablet
2024 ICD-10-CM Diagnosis Code R27.9 - ICD10Data.com
WebA Coding Region Determinant of Instability Regulates Levels of Manganese Superoxide Dismutase mRNA* Received for publication, May 14, 2001, and in revised form, August 3, 2001 Published, JBC Papers in Press, August 6, 2001, DOI 10.1074/jbc.M104378200 Christopher A. Davis‡, Joan M. Monnier§, and Harry S. Nick§¶ WebMar 21, 2024 · Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to … National Center for Biotechnology Information goodmorn plus